MIS B+ Implant

MIS B+ Overview.

MIS B+ biologic contact

B+ is a biological feature of MIS implants, that results in effective, long-term osseointegration. A mono-molecular layer of multi phosphonates is permanently bound to the surface of the MIS B+ implant, which is perceived as bone-like by the body.

The technology has been clinically demonstrated to result in visible bone growth directly on the surface of the B+ implant. The characteristics of B+ promote enhanced clinical performance with the possibility for earlier loading of the implant, better preservation of the bone levels around the implant, and longer-term implant survival, even in patients with compromised bone healing situations.

Molecules of B+ chemically bind to the implant surface, creating a hydrophilic surface, and remain stable throughout the life span of the implant. B+ features provide superior bone healing and implant integration. The phosphonated molecules have demonstrated high stability in terms of chemical and enzymatic degradation. These properties prevent the molecules from detaching from the implant surface, which allows them to remain present for the lifespan of the implant, providing bone attachment throughout each successive bone remodeling cycle.

This novel, phosphonate rich surface mimics one of the main constituents of bone, providing a significantly more favorable environment for implant integration. It has also been observed to accelerate the healing process, eliminate the “micro gap” between the bone and implant surface, and increase the fixation of the implant in bone.


Current literature demonstrates a linkage between improved bone healing and early osseointegration with the hydrophilicity of surface. MIS implant surface treatment combines sand-blasting and acid-etching. MIS surface treatment ensures surface purity and hydrophilic properties. B+ enhances the wettability of the implant surface, attracting water, proteins, and cells from the blood, enabling quicker cell adhesion and colonization, which results in faster bone matrix formation and osseointegration. The bone cells perceive the B+ treated implants as “bone” and thus migrate onto these surfaces very quickly.

Biomechanical Fixation
Once on the implant surface, a new bone matrix is quickly formed, maturing to organized, mineralized bone. The biomimetic characteristics of B+ allow for greater implant integration at earlier stages leading to long-term optimal osseointegration. The increased number of bone cells in contact with the MIS B+ implant results in enhanced biomechanical implant fixation very early on in the healing process. Increased fixation with B+ has been observed to reduce healing time.

Elimination of the “Micro-Gap”
In addition to mechanical interlocking resulting from the implant’s roughened topography, B+ also provides a chemical connection between bone and implant surface, eliminating the “micro-gap”. This results in early functional implant stability and fixation.

Stability in a Physiological Environment
The B+ molecule was shown to remain permanently bound to the implant surface throughout osseointegration, inflammation, and remodeling events. Furthermore unlike phosphates, phosphonated molecules such as B+ are enzymatically stable, ensuring that B+ will remain attached to the implant, and will not be released into the body over time.


MIS B+ implants are available in all MIS lengths and diameters for V3 and C1 implant systems.

MIS B+ Implant for C1 and V3