Bioteck®, a leader in the production of tissue substitutes of natural origin, has developed the exclusive deantigenation Zymo-Teck® process. The Zymo-Teck® process, unlike other processes based on high temperature treatments or using chemical solvents, uses enzymes, natural proteins able to precisely and selectively remove the various unwanted substances, making the tissues completely bio-compatible and devoid of treatment residues. Zymo-Teck® also preserves useful molecules, such as collagen in its natural structure and, operating at controlled temperatures, does not alter the structural characteristics of the tissues. The stringent in-line quality controls implemented by Bioteck® at all stages of processing guarantee the highest quality of grafts: to obtain the best surgical outcome.

Grafting bone collagen into the defect creates a precise biological condition: osteoblasts, the cells responsible for the formation of new bone tissue, produce collagen fibers that are then saturated by calcium minerals. It's the same three-dimensional structure of collagen that allows the nucleation of crystals of bone apatite, through a physical phenomenon called epitaxy. In addition, the type I bone collagen stimulates, both at cellular and subcellular level, an extremely high number of processes involved in bone regeneration. The presence of bone collagen in OX® is also demonstrated in polarised light: collagen fibres, having a regular texture, presents a refractivity characteristic that makes it look lighter.

OSTEOXENON® is reworked and reabsorbed through the action of osteoclasts. This happens with entirely physiologic kinetics resulting in the complete remodeling of the OSTEOXENON® grafts with patient's bone. This is possible because OX®, unlike other materials, is recognized as the optimum substrate by osteoclasts that reabsorb it physiologically; only in this case, in fact, the regenerative process may end with the complete replacement of the graft. If the material is remodeled and is reabsorbed physiologically there can be no loss of volume. If the material is reabsorbed too quickly (e.g. calcium phosphate) or too slowly (e.g. synthetic hydroxyapatites) the volume of new endogenous bone is not equal to the grafted volume. OSTEOXENON®, however, by remodeling itself through osteoclastic activity, it keeps the grafted volume.